1. Cas9X®基因敲除服务：影响因子为39.3

Ma B, Ju A, Zhang S, et al. Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease[J]. Signal Transduction and Targeted Therapy, 2023, 8(1): 229.

【ALB in HepG2 was knocked out by Haixing Biosciences using the CRISPR/Cas9 system】

2. Cas9X®基因编辑服务(突变菌的基因改造和筛选)：影响因子为26.6

Wu W, Pu Y, Gao S, et al. Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy[J]. Nano-Micro Letters, 2022, 14(1): 1-21.

3. Cas9X®基因敲除服务：影响因子为16.6

Bu J, Zhang Y, Wu S, et al. KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer[J]. Nature Communications, 2023, 14(1): 2602.

4. Cas9X®载体：影响因子为15.1

Chen X, Hao Y, Liu Y, et al. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer[J]. Advanced Science, 2023, 10(32): 2302705.

5. Cas9X®基因敲除服务：影响因子为14.9

Cao X, Zheng J, Zhang R, et al. Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@ DNA probe[J]. Nucleic Acids Research, 2024: gkae202.

6. AV腺病毒 lncRNA LITTIP：影响因子14.9

Li T, Wang H, Jiang Y, et al. LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling[J]. International Journal of Oral Science, 2023, 15(1): 33.

7. Cas9X®基因过表达服务：影响因子为14.5

Fan H, Jiang H, Yu Z, et al. Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma[J]. Acta Pharmaceutica Sinica B, 2024.

8. Cas9X®基因敲除服务：影响因子为12.8

Yang H H, Jiang H L, Tao J H, et al. Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury[J]. Experimental & Molecular Medicine, 2022, 54(11): 2077-2091.

9. Cas9X®基因敲除服务：影响因子为12.478

Liu B, Hua D, Shen L, et al. NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover[J]. Theranostics, 2024, 14(5): 2058.

10. 腺病毒包装：影响因子为11.4

Liu L, Wang L, Liu L, et al. Acyltransferase zinc finger DHHC-type containing 2 aggravates gastric carcinoma growth by targeting Nrf2 signaling: A mechanism-based multicombination bionic nano-drug therapy[J]. Redox Biology, 2024, 70: 103051.

11. 慢病毒包装：影响因子为10.2

Chen W, Li Z, Yu N, et al. Bone-targeting exosome nanoparticles activate Keap1/Nrf2/GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells[J]. Journal of Nanobiotechnology, 2023, 21(1): 355.

12. 慢病毒过表达载体：影响因子为10.2

Peng W, Xie Y, Luo Z, et al. UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury[J]. Journal of Nanobiotechnology, 2023, 21(1): 225.

13. shRNA质粒：影响因子为9.3

Li W, Ali T, Zheng C, et al. Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression[J]. Journal of neuroinflammation, 2021, 18: 1-19.

14. Cas9X®基因敲除服务：影响因子为9.2

Zhong S, Guo Q, Chen X, et al. The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer[J]. International Journal of Biological Sciences, 2024, 20(3): 916.

15. CRISPR干扰服务：影响因子为7.9

Liu X, Yan C, Chang C, et al. Ochratoxin A promotes chronic enteritis and early colorectal cancer progression by targeting Rinck signaling[J]. Phytomedicine, 2024, 122: 155095.

16. Cas9X®基因敲除服务(敲除质粒/过表达质粒)：影响因子为7.2

Dai J, Zhang L, Zhang R, et al. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency Is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis[J]. Cellular and Molecular Gastroenterology and Hepatology, 2024, 17(3): 399-421.

17. Cas9X®基因敲除服务：影响因子为5.8

Zhou T, Qian H, Zhang D, et al. PGRN inhibits CD8+ T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM[J]. Cancer Immunology, Immunotherapy, 2024, 73(5): 76.

18. Cas9X®基因敲除服务：影响因子为5.6

Xu B, Sui Q, Hu H, et al. SAMHD1 attenuates acute inflammation by maintaining mitochondrial function in macrophages via interaction with VDAC1[J]. International Journal of Molecular Sciences, 2023, 24(9): 7888.

19. Cas9X®基因敲除服务：影响因子为5.6

Zhong W J, Ma L, Yang F, et al. Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia[J]. Frontiers in Pharmacology, 2022, 13: 1027441.

20. 基因敲除试剂盒(CRISPR-Cas9x3.0)：影响因子为5.1

Xiao P, Chen J, Zeng Q, et al. UNC5B Overexpression alleviates peripheral neuropathic pain by stimulating netrin-1-dependent autophagic flux in Schwann cells[J]. Molecular Neurobiology, 2022, 59(8): 5041-5055.

21. siRNA干扰：影响因子为4.7

Huo D, Liang W, Wang D, et al. Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis[J]. Neuropharmacology, 2024, 247: 109812.

22. Cas9X®基因敲除服务：影响因子为4.7

Lu Y, Zhang M X, Pang W, et al. Transcription factor ZNF683 inhibits SIV/HIV replication through regulating IFNγ secretion of CD8+ T cells[J]. Viruses, 2022, 14(4): 719.

23. Cas9X®基因载体服务：影响因子为3.9

Kang J, Abudurufu M, Zhang S, et al. lncRNA VIM-AS1 acts as a prognostic biomarker and promotes apoptosis in lung adenocarcinoma[J]. Journal of Cancer, 2023, 14(8): 1417.

24. Cas9X®基因稳转服务：影响因子为3.4

Liang C, Zhou J, Wang Y, et al. Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma[J]. Journal of Bone Oncology, 2024, 44: 100517.

25. Cas9X®基因过表达服务：影响因子为2.7

Li C, Lin X, Su J. HSP90B1 regulates autophagy via PI3K/AKT/mTOR signaling, mediating HNSC biological behaviors[J]. PeerJ, 2024, 12: e17028.

26. 细胞STR鉴定服务：影响因子为2.7

Wang C, Liu P, Sun Y, et al. Prognostic biomarker SYK and its correlation with immune infiltrates in glioma[J]. Experimental and Therapeutic Medicine, 2023, 26(4): 1-11.

27. Cas9X®基因编辑服务：影响因子为11

Li W, Ali T, Zheng C, et al. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes[J]. Molecular Psychiatry, 2022, 27(2): 1047-1058.

28. 稳定转染过表达

Wang D, Yang S, Zeng Y, et al. TET2 amplifies RIPK3/MLKL necroptosis signal by upregulation of PLK3 to promote UVB-induced skin photodamage[J]. 2023.

29. Cas9X®基因敲除服务

Zhou T, Qian H, Zhang D, et al. Tumor-Derived PGRN Inhibits Cd8+ T Cell Recruitment and Promotes the Progression of Breast Cancer by Up-Regulation of ICAM-1 on TAM[J]. Available at SSRN 4204772.

30. Cas9X^®基因敲除服务：影响因子为14.3

Wei Y S, Tang W J, Mao P Y, et al. Sexually Dimorphic Response to Hepatic Injury in Newborn Suffering from Intrauterine Growth Restriction[J]. Advanced Science, 2024: 2403095.

31. Cas9X^®慢病毒包装：影响因子为14.3

Li C, Qin T, Zhao J, et al. Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair[J]. Bone Research, 2024, 12(1):

32. Cas9X^®基因干扰siRNA：影响因子为9.1

Bian Y, Xu S, Gao Z, et al. m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/FOXM1 positive feedback loop[J]. Cancer Letters, 2024: 217004.

33. Cas9X^®基因编辑服务：影响因子为5.7

Zhou Z, Hu C, Cui B, et al. Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo[J]. Journal of Agricultural and Food Chemistry, 2024.

34. Cas9X^®基因干扰siRNA：影响因子为4.6

Wu Q, Yuan K, Yao Y, et al. LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage[J]. Experimental Neurology, 2024, 376: 114776.

35. 质粒：影响因子3.8

Li Y, Wang Y, Wu R, et al. HTR2B as a novel biomarker of chronic obstructive pulmonary disease with lung squamous cell carcinoma[J]. Scientific Reports, 2024, 14(1): 13206.

36. Cas9X^®基因敲除服务：影响因子为3.8

Cui N, Han X, Yang X, et al. Avian leukosis virus usurps the cellular SERBP1 protein to enhance its transcription and promote productive infections in avian cells[J]. Poultry Science, 2024, 103(6): 103755.

37. Cas9X^®载体：影响因子为3.2

Cui Z, Feng Y, Gao Y, et al. Overexpression of YTHDF3 increases the specific productivity of the recombinant protein in CHO cells by promoting the translation process[J]. Biotechnology Journal, 2024, 19(4): 2400078.

38. 质粒：影响因子1.5

Zhou Q, Chen D, Yu J, et al. A novel gain‐of‐function STAT3 variant in infantile‐onset diabetes associated with multiorgan autoimmunity[J]. Molecular Genetics & Genomic Medicine, 2024, 12(2): e2407.

39. Cas9X®基因敲除服务

Zeng F, Heier C, Yu Q, et al. Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis[J]. bioRxiv, 2024: 2024.04. 14.589399.

40. AVV病毒包装

Li X, Wang J, Liao C, et al. The binding of PKCε and MEG2 to STAT3 regulates IL‐6‐mediated microglial hyperalgesia during inflammatory pain[J]. The FASEB Journal, 2024, 38(8): e23590.

41. THP1细胞基因突变：影响因子为14.7

Liang J, Wan Y, Gao J, et al. Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia[J]. Nature Communications, 2024, 15(1): 1-17.

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